2024 Advancements in Longevity
2024 was a groundbreaking year in longevity science.
Researchers made significant progress in understanding and potentially manipulating the aging process, as well as in identifying promising approaches for extending healthspan.
Here are a few of the highlights that make us glad to work in this field every day:
Biomarker Advancements: Development of new biomarkers and "aging clocks" to better measure biological age and assess the effectiveness of anti-aging interventions.
AI for Longevity Research: 2024 brought an increased use of artificial intelligence to analyze genetic data and accelerate the discovery of aging-related patterns and potential interventions.
Senescent Cell Detection: Researchers developed AI tools to accurately identify senescent cells, which could accelerate the development of senolytic treatments for age-related diseases
Senolytic Therapies: Advancements in senolytic therapies to remove senescent cells and potentially extend healthspan.
Regenerative Medicine: Scripps Research developed small molecule drugs that act on endogenous stem cells to repair tissues damaged by age-related diseases, currently in clinical trials for conditions like osteoarthritis, inflammatory bowel disease, and heart failure.
Cellular Reprogramming: Scientists demonstrated the ability to reprogram T cells to slow down and even reverse aging in mice, showing potential for eliminating senescent cells
Epigenetic Discoveries: Development of DunedinPACE, an algorithm that could help test age-slowing interventions and identify individuals aging faster than normal.
